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doi: 10.1007/s40618-017-0799-3

[1] [2] Semaglutide mimics the action of the naturally occurring hormone GLP-1, which is released from the intestine after eating

Pillar 7: Metformin (mostly hepatic) Metformin is often described as a general insulin sensitiser, but mechanistically, its clinically relevant effects are largely hepatic (liver)

This comprehensive research timeline provides substantial evidence regarding efficacy, safety, and cardiovascular benefits across diverse patient populations, making semaglutide one of the most thoroughly studied medications in its class

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