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Patients with a BMI over 40 are unlikely to receive sufficient benefit from weight loss medications alone

European Journal of Pharmaceutical Sciences

Shepherd noted that women who take medications for weight loss during menopause should pay special attention to their diet and exercise in order to not exacerbate the loss of muscle mass and bone density already common among menopausal women

Because of their intermittent stimulation of the GLP-1R, short-acting GLP-1RAs retain their ability to delay gastric emptying leading to lower postprandial glucose excursions compared with the long-acting GLP-1RAs, which are associated with the development of tolerance (tachyphylaxis) to GLP-1s effect on gastric emptying (10)