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Formulation R1 (3 mg, 7 mg, 14 mg) Weeks 1-4: 3 mg once daily (starting dose, not effective for blood sugar control) Weeks 5-8: 7 mg once daily Week 9 onward: Stay on 7 mg if effective, or increase to 14 mg once daily if more control is needed Formulation R2 (1.5 mg, 4 mg, 9 mg) Weeks 1-4: 1.5 mg once daily Weeks 5-8: 4 mg once daily Week 9 onward: Stay on 4 mg if effective, or increase to 9 mg once daily if more control is needed Who can use it

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SGLT2 inhibitors during pregnancy Animal None of the SGLT2 inhibitors showed developmental toxicity when a dose not resulting in maternal toxicity was administered during the interval coinciding with the first trimester period of organogenesis except for canagliflozin, where ossification delays of the metatarsal bones were seen ( Table 2 )

Individuals with G6PD Deficiency (glucose-6-phosphate dehydrogenase), a genetic enzyme disorder, should avoid use of methylene blue