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Cell 75: 7382, 1993

Semaglutide (Ozempic/Wegovy), tirzepatide (Mounjaro/Zepbound), and retatrutide represent distinct molecules within this class

[15] Semaglutide is a peptide similar to the hormone glucagon-like peptide-1 (GLP-1), modified with a side chain, and acts as a GLP-1 receptor agonist

Since GLP-1R are absent, or are present only at very low levels on hepatocytes, it was also expected that in the absence of ethanol or nutrient regulation GLP-1R agonism would not affect ethanol-metabolizing enzymes

"As it relates to bolt-on acquisitions, in the near term you would not expect us to do much there," Pfizer Chief Financial Officer David Denton said during an earnings call on May 1