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Curr Opin Endocrinol Diabetes Obes 32(1): 3443

For the primary endpoint at week 104, the authors report that in evoke, the mean CDR-SB change from baseline was 2.3 (SE 0.1) with semaglutide and 2.3 (0.1) with placebo, with an estimated between-group difference of 0.08 (95% CI 0.35 to 0.20
The only way to know is a careful trial starting at the lowest dose with slow titration

Mastering injection technique ensures you get the full therapeutic benefit while minimizing discomfort
