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Important safety considerations include an increased risk of hypoglycemia when used with insulin or sulfonylureas, and a boxed warning about thyroid C-cell tumors (contraindicated in patients with personal/family history of medullary thyroid carcinoma or Multiple Endocrine Neoplasia syndrome type 2)

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Aug 22 2022;42:115-144

Type 2 diabetes itself is associated with an increased risk of cognitive impairment and dementia, mediated by mechanisms including chronic hyperglycaemia, vascular damage, and inflammation
