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Preparing Your Injection Site and Skin Select an injection site on your abdomen, thigh, or upper armareas with adequate subcutaneous tissue to prevent hitting muscle
The increased risk of amputation seen in the large, long-term Canagliflozin Cardiovascular Assessment Study (CANVAS) trial for canagliflozin, and select observational studies, merits further research but overall, there is currently no consistent evidence of SGLT2i exposure and increased risk of amputation
Demographic weighting targets come from the 2019 American Community Survey
Their average body mass index (BMI) was 35, meeting the threshold for clinical obesity, and 86 had type 2 diabetes
