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GLP-1 RAs exert direct and indirect effects on the CV system including vasodilation, natriuresis anti-atherosclerotic effects, improvements in endothelial function, anti-inflammatory effects (decrease cytokines level such as tumor necrosis factor, interlukin-1, interlukin-6) and a consequent decrease in C-reactive protein, and reductions in infarct size (60, 84, 85)

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