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examined 224 IBD patients on GLP-1 receptor agonists and found no significant change ( p = 0.36) in the rates of IBD exacerbation (measured as a composite of IBD-related hospitalizations, steroid prescriptions, medication escalation or adjustments, or IBD-related surgeries) after 12 months of GLP-1 RA therapy, compared to the 12 months prior to treatment [36]

And a not-insignificant minority of patients point to a lack of efficacyeither insufficient weight reduction or lack of significant decrease in blood glucose levels

Bitter Melon contains compounds which can mimic insulin and may stimulate GLP-1 release

On average, people achieved weight loss ranging from around 5% to more than 10% of their initial body weight over the course of the trials, which generally lasted around six months to a year