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Once the patient is stabilized on a dose, monitoring intervals typically extend to every 12 weeks, then to every 6 months

GLP-1 RAs exert direct and indirect effects on the CV system including vasodilation, natriuresis anti-atherosclerotic effects, improvements in endothelial function, anti-inflammatory effects (decrease cytokines level such as tumor necrosis factor, interlukin-1, interlukin-6) and a consequent decrease in C-reactive protein, and reductions in infarct size ( Figure 2 Recently, GLP-1 RAs have been recommended by different guidelines

Can I skip the titration and start at a higher dose

, Paracrine Interactions Within the Pancreatic Islet Determine the Glycemic Set Point, Cell Metabolism 27, no

While some indicate an improvement in parameters associated with depression (98), others show an increased risk, especially after longer periods of drug exposure and with the newer drugs with a longer half-life (99, 100), though some other studies indicate a higher risk with liraglutide compared to semaglutide (which in that particular study was associated with reduced risk for psychiatric events) (101)