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Novo Nordisk has made clear, however, that the two products are not interchangable as they are licensed for different conditions, have different doses and require different clinical assessments

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Thereafter, the glipizide dose was to be kept constant, except for down-titration to prevent hypoglycemia

Moreover, abnormalities in this axis and in cortisol levels can be related to higher cardiovascular risk [164, 165], which may explain the increase in the mortality rate and in the cardiovascular risk factors prevalence observed in affective disorders, including BD [166]

The critical difference between a drug on the 503B list and an FDA-approved medication is the level of scrutiny, he continued