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These events are dose-dependent and most pronounced during dose escalation

Jornayvaz, Lausanne (Diabtologie)

But there have also been troubling side effects reported

According to our experience in rats, the parenteral administration of ghrelin at a dose that raised plasma hormone to the level observed under fasting conditions, significantly attenuates plasma levels of leptin, while markedly increasing food intake

We have also identified gastrointestinal distension stimuli [53] and the rare sugar d-allulose [54] as non-caloric stimulators of GLP-1 release
