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These effects are possibly mediated through mechanisms that include, but are not limited to, improved glycemic control, reduced hepatic lipid production, enhanced fatty acid oxidation, and upregulated LDL receptor activity [52], offering a multifaceted therapeutic strategy for both diabetes and its associated metabolic disturbances

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Continued advancements in nanoparticle design and administration routes, such as receptor-mediated transcytosis and intranasal delivery, hold significant promise for translating GLP-1RAs therapies into effective, disease-modifying treatments for AD
