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This, in turn, stimulates downstream signaling elements dependent on both protein kinase A (PKA) and exchange protein directly activated by cAMP (EPAC) activation, which triggers the opening of voltage-dependent calcium channels (VDCCs), resulting in insulin exocytosis [24, 25]
This association emphasizes the potential metabolic impact of BED beyond weight-related outcomes, highlighting the importance of addressing BED in the management of metabolic health [14]
10.1001/jamanetworkopen.2024.21305
it involves complex metabolic, hormonal, and lifestyle factors
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