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Even small temperature swings, repeated over days, chip away at its effectiveness in ways you cannot see, smell, or feel until your results start sliding backward

For example, dulaglutide (Trulicity) is only authorised for type 2 diabetes, while semaglutide 2.4mg (Wegovy) and liraglutide 3mg (Saxenda) have specific authorisations for weight management with eligibility criteria defined by NICE guidance

The delayed gastric emptying is stronger, nausea is more likely, and the GERD risk with lying down increases

Tirzepatide is showing a similar impact but is not yet FDA approved for this indication

No mixing, no reconstitution, no bacteriostatic water