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For someone targeting a 10-pound loss, these same biological effects can help create the modest calorie deficit needed to reach that goal

This suggests a potentially better lean mass to fat mass loss ratio with tirzepatide but the trials used different populations and protocols so direct comparison requires caution

Participants were assigned to: GLP-1 medication (liraglutide) CPAP therapy (a breathing machine for sleep apnea) Both GLP-1 + CPAP Special PET-CT scans measured how active each persons visceral fat was in other words, how much energy it was burning

Although the direct inhibition of DPP-4 activity does not seem to regulate bone remodeling, the impact of DPP-4 on bone metabolism is indirect, involving the modulation of DPP-4 substrates and inflammation within the bone microenvironment

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