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Firths logistic regression further demonstrated a good model fit (pseudo-R2 of 0.943), but the individual predictors (glucagon-like peptide-1 (GLP-1) type, age, and BMI) were not statistically significant

Understanding the underlying mechanisms, your individual biomarker profile, and evidence-based management strategies can help you have a more informed conversation with your healthcare provider about optimizing your treatment e

Approaches such as simultaneous low-dose initiation, careful titration, and close monitoring can help manage tolerability concerns and improve adherence to ARNI therapy

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Meanwhile, orforglipron demonstrated significant weight loss efficacy [8] consistent with injectable GLP-1 medicines