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Plasma DPP-4 activity ( A , C , E , and G ), plasma TG and AUC over 180 minutes ( B , D , F , and H , left and middle), and plasma levels of active GLP-1 before and 10 minutes after oral gavage of olive oil ( B , D , F , and H , right) during a lipid tolerance (LTT) in response to water or gut-selective (14 g/mouse) or systemic (10 mg/kg) dose of sitagliptin in 10- to 13-week-old Dpp4 EC+/+ ( A and B , n = 1822 for TG, n = 819 for other groups), Dpp4 EC/ ( C and D , n = 1216 for TG, n = 618 for other groups), Dpp4 EC+/+ (BMT) ( E and F , n = 68 for TG, n = 412 for other groups), and Dpp4 EC/ (BMT) ( G and H , n = 68 for TG, n = 412 for other groups) mice fed a regular chow (RC) diet

Glucagon-Like Peptide-1 (GLP-1) agonists are a class of medications originally developed for the management of type 2 diabetes

224 Physiological properties of the body, including organ mass and volume, blood flow rate, plasma protein levels, and the abundance of enzyme and transporter expression, are mathematically described within the model

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I think the side effect numbers look intimidating on paper, but the real-world experience is often much milder than people expect