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There were also limited interactions between GH5 subunit and helix 8 of the receptor (E392 GH5 , N440 8.47b and G441 8.48b )

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After administration of Triple GLP-1/GIP/glucagon receptor agonist, learning and memory impairment of AD models (APP/PS1 mice and 3Tg-AD mice) was improved, amyloid plaques, tau pathology, inflammation response and oxidative stress in brains of two AD models were ameliorated (239241)

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