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Independent predictors of amputation identified in the study included prior amputations, male sex, non-Asian ethnicity, history of PAD, history of neuropathy, albuminuria, and elevated HbA1c levels at baseline.38 While this finding was not replicated in other randomized clinical trials on SGLT-2 inhibitors, it is recommended to conduct a thorough screening for risk factors for amputations when initiating SGLT2 inhibitors

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