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This review article examines the translational evolution of glucagon-like peptide-1 receptor agonists (GLP-1RAs), tracing their progression from the discovery of exendin-4 in Gila monster venom to long-acting peptide analogues and the first orally delivered peptide therapy, oral semaglutide

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GLP-1 analogs were administered for 21 days to MC4R KO mice and compared their efficacy

Adverse dietary stimuli can compromise microglial homeostasis that is not reversed by semaglutide.