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The increased demand for GLP-1 RAs has been primarily driven by their clinically proven effectiveness in diabetes, weight loss, and cardiovascular disease management (Yao et al., 2024

The sparse treatment options with divergent results have led to a search for novel treatment strategies against AUD, and one of the molecular targets has been the glucagonlike peptide1 (GLP1) receptor (GLP1R) [15]

High and low engagement groupings measured by quantile of app opens

Over time, Ca 2+ influx eventually failed to produce exocytosis suggesting that the readily-releasable pool can be depleted

Ongoing advancements in research and development have resulted in the production of GLP-1RA with increasingly prolonged half-lives GLP-1 GLP-1RAs