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Vascular Protection Investigations in vascular calcification models showed: Attenuation of vascular smooth muscle calcification via AMPK activation Reduced expression of osteogenic markers in vascular tissue Protection against secondary myocardial remodeling Prevention of age-related vascular dysfunction Aging and Longevity Research Cellular Aging and Senescence Research examining MOTS-c in aging models revealed: Plasma MOTS-c levels decline approximately 21% between ages 18-30 and 70-81 years in humans Treatment delayed age-related functional decline in multiple mouse organ systems Improved stress resilience in aged mesenchymal stem cells Enhanced mitochondrial homeostasis in aged tissues Studies correlating endogenous MOTS-c levels with aging biomarkers suggest its decline contributes to age-related metabolic deterioration