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The implications are significant: Repurposing an inexpensive, widely available drug Targeting the intersection of inflammasome activation, TP53 dysfunction, and neoplastic risk Potential relevance for disorders ranging from CAPS and histiocytosis to MDS and beyond We urgently need more translational work on this underappreciated molecule

However, the earliest signal priming the cephalic phase response is food quality reflected by smell and taste, which, moreover is the key driver for the reward driven hedonic eating
The authors conclude: In this real-world study where half of patients discontinued GLP-1-based treatment within a year after initiation, not losing weight was associated with worse clinical outcomes while larger reductions were associated with decreased risks
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