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Even the people who invented Wegovy and Ozempic have mentioned that there are concerns that they have users who may develop almost like existential ennui, like boredom, because of how little food they're eating and how connected food is to reward center

Looking at the imaging data, a clinically significant reduction in liver fat content based on MRI-PDFF ranged from 57% to 67% in participants receiving survodutide compared to 14% of those on placebo

Second, we highlighted how ghrelin and GLP-1 differentially modulate reward phases, with a specific focus on different clinical populations including obesity, T2D, eating disorders, alcohol use disorder, and depression