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Bioorg Med Chem
Its possible that GLP-1s may be useful for a range of substance use disorders, including opioid use disorder and nicotine use disorder, Varisco says

Therapy may be able to make changes in your epigenetic profile to some extent, but the neuronal loss, synaptic loss, all those things, there's no evidence that psychotherapy reverses those losses

This dual-action mechanism is why tirzepatide has generated significant clinical interest

doi: 10.1124/jpet.118.254821 63 TonneijckL.MuskietM
