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Gastrointestinal Effects The most commonly reported adverse effects are gastrointestinal in nature, including: Nausea and vomiting (affecting 20-40% of patients initially, varying by agent and dose) Diarrhoea or constipation Abdominal discomfort and bloating Reduced appetite In elderly patients, persistent nausea and vomiting can lead to dehydration and electrolyte imbalances more rapidly than in younger adults

Professional consultation is required prior to self-administering GLP-1

Diabetes care 34 , 20412047, doi:10.2337/dc11-0291 (2011)

The in vivo actions of compound 60 (Figure 7) were also established, including the reduction of plasma DPP-4 activity and the control of rising blood glucose levels

Regular bloodwork monitoring is the gold standard for nutritional optimization