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ApoE knockout mice were divided into early diabetes (dosed from 10 to 22 weeks of age), late diabetes (dosed from 18 to 30 weeks of age), and non-diabetic groups after streptozotocin treatment, and each group received semaglutide, tirzepatide, or saline for 12 weeks

These results indicate that recombinant 6mGLP-1 has great potential to be used as an effective and cost-efficient drug for the treatment of type 2 diabetes.

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