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This is a composite, and individual results vary widely but it captures a pattern I now see often enough that I ask about metabolic inflammation at nearly every RA visit

In animal studies, glucagon-like peptide-1 receptor agonists consistently reduce drug intake, attenuate dopamine release in reward circuits, and decrease relapse-like behavior

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Like nausea, diarrhea may improve over time with continued use of the medication

The internal commentary was gone