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Consequently, activation of these receptors produces a small but consistent chronotropic effect
Its first-mover advantage, combined with strong reimbursement coverage in major developed markets, has made it the reference molecule for obesity pharmacotherapy
In particular, glucagon has firmly been demonstrated to enhance hepatic lipid metabolism, Hepatic GCGR agonism leads to upregulation of lipid catabolism pathways in the hepatocyte where a number of key regulatory transporters and enzymes facilitate beta oxidation of fatty acids (61)
