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Description
Both the STEP-1 and SURMOUNT-4 trials included the availability of RDN dietary counseling and recommendations to exercise 150 min/week during the treatment period, but with notable weight regain for most participants upon GLP-1 discontinuation without continued nutrition support [18,273]

Amylin, GIP, glucagon, leptin-related biology, muscle preservation, inflammation, and liver-directed mechanisms may all become part of the treatment landscape
Unlike older medications such as phentermine or orlistatwhich suppress appetite via the central nervous system or block dietary fat absorptionsemaglutide enhances feelings of fullness and reduces hunger, helping our patients decrease their calorie intake more effectively

What are GLP-1 Agonist Medications
Tau beats amyloid in predicting brain atrophy in Alzheimer disease: implications for prognosis and clinical trials