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[24] [25] Physical activity also improves insulin sensitivity independent of weight loss, enhancing the metabolic improvements already achieved through semaglutide's glucose-lowering effects

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GI side effects are common to both compounds but may be more pronounced with retatrutide

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The formulation of semaglutide that is developed by a compounded pharmacy is not required to be reviewed by the FDA prior to being available to the patient, and formulations are up to the discretion of the pharmacists and physicians involved in the compounding process