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Sleep quality, stress levels, and physical activity also modify your metabolic response independent of the medication itself

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This effect induces your body to create a healing response

Thus, in overweight/obese women with PCOS, combination treatment is more effective than metformin alone by improving insulin sensitivity, with tolerable short-term side effects (201)

This paper reviews the physiological, pharmacologic, and clinical foundations linking GLP-1 RA therapy to reproductive outcomes
