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Unlike older weight loss drugs or lifestyle changes in isolation, retatrutides effect on liver fat and glycemic control can potentially assist with more facets of metabolic health

In early August, Novo Nordisk announced that Wegovy reduces the risk of heart attack, stroke or heart-related death in people with cardiovascular disease and obesity by 20%, a result expected to boost use of the medicine even further

phentermine Other common alternatives include Contrave (naltrexone/bupropion), Xenical (orlistat), and, for people with Type 2 diabetes, metformin or Ozempic, which may be more likely to be covered by insurance

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although generally considered safe, their chronic use in the context of supraphysiologic androgen exposure and cardiac remodeling has not been systematically studied