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Then, the researchers administered exendin-4 via intrathecal injection to the experimental rats and observed a reduction in pain sensitivity, alleviation of neural inflammation, and suppression of inflammatory factors such as IL-1, TNF-, and iNOS

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The injection itself causes microscopic bleeding into surrounding tissue, and your body gradually reabsorbs this blood over 1-3 weeks, creating the characteristic purple-to-yellow color progression

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This is increasingly relevant for disease areas such as obesity and cardiometabolic diseases, where metabolic phenotypes could differ from other patient populations.1719 To address this, the SHL research team conducted a series of soft tissue user ( in vivo ) studies, simulation ( in silico ) studies and physical test ( in vitro ) studies, providing a mechanistic view of the interactions between the autoinjector and human soft tissue during injection activation (Figure 3)