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Discussion In the present study, we found that GLP-1R protein levels decreased significantly in a knee OA rat model induced by monoiodoacetate, which was accompanied by the downregulation of the PKA/CREB pathway and upregulation of the inflammation-related proteins TNF-, IL-6 and IL-1

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Annals of Emergency Medicine , 81, 249-261

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2 However, this trial used the higher 2.4 mg dose (Wegovy), not the Ozempic doses

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