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The trial aimed to evaluate if semaglutide, a once-weekly GLP-1 receptor agonist, would mitigate kidney outcomes and death

These effects are still being studied, but early results are promising

But the phase 2 clinical trial data on standard dosing, plus a growing body of community reports, are positive

Tirzepatide (Mounjaro, Zepbound) shows similar nausea incidence but adds dual GIP-receptor activation, which may increase gastrointestinal effects in some patients

Yashaeva L, Montoya M, Joshi J, Stephens A, McNulty O, Kaur G (2025) Advancing care in Alzheimers disease: current treatments and their impact on quality of life