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Description
Dedicated MASLD/MASH trials for both compounds will clarify whether retatrutide's glucagon-mediated hepatic fat clearance translates into superior histological outcomes

Footnotes CONFLICTS OF INTEREST No potential conflict of interest relevant to this article was reported
S.KrarupN.et al (2023)

The most commonly reported side effects during the first month are gastrointestinal, including nausea, vomiting, diarrhoea, and constipation, consistent with other GLP-1-containing therapies
The enzyme doesnt wait for the hormone to circulate it cleaves GLP-1 in the gut wall and portal vein on the way to the heart
