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The test examines 14 different peptide pathways and 150+ genetic insights, including variants in GLP1R (rs6923761), GIPR (rs1800437), FTO (rs9939609), and MC4R (rs17782313) that directly affect appetite regulation, weight loss response, and metabolic efficiency

Expert Rev Endocrinol Metab 2011;6:557561 [DOI] [PMC free article] [PubMed] [Google Scholar] 4

Glucagon stimulates energy expenditure in the following ways: (1)activation of BAT via direct glucagon receptor activity and indirect fibroblast growth factor 21 (FGF 21)-dependent pathways with downstream effects of increased oxygen consumption (an indirect measure of heat production)