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Semaglutide, as an agonist, binds to the GLP-1 receptor and works to lower blood glucose by stimulating insulin secretion and to inhibit glucagon release

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Measures of cardiovascular risk factors were evaluated in the DURATION trials

10.1053/j.gastro.2024.03.015 [DOI] [PubMed] 26.Van de Putte P, Vernieuwe L, Jerjir A, Verschueren L, Tacken M, Perlas A (2017) When fasted is not empty: a retrospective cohort study of gastric content in fasted surgical patients

The beneficial effect of tirzepatide on hsCRP, a biomarker of systemic inflammation, YKL-40, a proinflammatory cytokine, and ICAM-1, a biomarker of endothelial dysfunction, was already detectable at 4 weeks, consistent with the salutary effects of GIP and GLP-1 on inflammation and atherosclerosis in experimental models [84,85,86]