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The risk profile is not only clinical but also regulatory , requiring vigilance at the dispensing stage
doi: 10.3390/cimb44080239

The impetus to prescribe GLP-1 RAs primarily for obesity is continually growing

As clinicians tried higher doses in clinical trials for diabetes, they began to notice patients spontaneously losing weight

High-dose niacin supplements should be avoided, as they can impair insulin sensitivity and raise glucose levels, potentially counteracting the benefits of tirzepatide