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Only two of the five showed a statistically significant reduction in absolute mass, and the drops were modest (about 10%)

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Phentermine's sympathomimetic stimulation combined with semaglutide's direct cardiovascular effects creates compounded stress on the heart, particularly in people with existing hypertension or arrhythmia history

GLP-1RAs thus prevent the occurrence of retinal damage associated with oxidative-stress-induced activation of glial cells and collectively foster a healthy retinal microenvironment by virtue of preventing cellular overexertion [94, 100]