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Abstract Background/Objectives : Glucagon-like peptide-1 receptor agonists (GLP-1RAs) have revolutionized the treatment of type 2 diabetes and obesity

Methods Study cohort (SURMOUNT-1 clinical trial) Ethical approval and study populations The study was conducted in accordance with the principles of the Declaration of Helsinki, Good Clinical Practice guidelines and all applicable regulatory requirements Study protocol and informed consent documents were approved by independent ethics committees and institutional review boards at all participating trial sites

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Looking at the medical data of more than 73,000 older adults, the researchers who conducted the study concluded that participants who expended more energy on a regular basis through moderate-to-vigorous exercise had a 14%40% lower risk of dementia, anxiety, depression, stroke, and even sleep disorders, compared to more sedentary peers