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C57BL/6 male mice were housed (25 mice per cage) under a 12-hour-light/dark cycle in the Toronto Centre for Phenogenomics (TCP) facility

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Advise patients who have repeatedly injected into areas of lipodystrophy or localized cutaneous amyloidosis to change the injection site to unaffected areas and closely monitor for hypoglycemia

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The evidence comes from clinical observation and individual patient outcomes

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