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HOMER motif analysis of the differentially up- or down-regulated genes in semaglutide-treated liver mesenchymal cells revealed an enrichment of HNF transcription factor family motifs in genes upregulated with semaglutide ( Figure S7F )

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Similarly, rTOSS and iTOSS were calculated as the sum of patients scoring of 3 individual ocular symptoms (itching/burning, tearing/watering, and redness) on a 0 to 3 categorical severity scale (0=absent, 1=mild, 2=moderate, and 3=severe)