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YesOzempic may influence dopamine and reward pathways, though not in the same direct way as psychiatric medications or addictive substances

Adipokines (e.g., leptin and adiponectin) are regulated by DPP-4 and may influence bone remodeling and energy metabolism in a paracrine manner

Semaglutide changes how your body signals hunger, but smart nutrition choices amplify results

There's also data suggesting that in some cases, people who take GLP-1s for several years can start to experience a waning effect - perhaps a drug resistance - where they start to regain some weight, even while taking the medication

Common side effects (may affect up to 1 in 10 people)