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A class of medications targeting glucagon-like peptide-1 (GLP-1) receptors have shown significant efficacy in weight reduction (4)

However, plasma concentrations of semaglutide at steady state are estimated to be about 100 times lower than the IC 50 values for OATP1B1/3 (3.50 M and 2.95 M, respectively).56 Moreover, when BSA was added, the inhibitory effect disappeared or was diminished, probably due to the binding of the fatty acid residues of GLP-1 RAs and a dual GLP-1/GIP RA to BSA.70 Table 3

11 The team of Jens Juul Holst at the University of Copenhagen in Denmark published a report in FEBS Letters, reaching the same conclusion in January 1987

B.BuszaG.HolmesC.RitchieC.et al (2019)

Dushay cited hopes that pill versions of GLP-1 drugs could ease shortages, come at lower cost and enhance convenience