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Cotadutide's modest results, in addition to its high rate of treatment discontinuation due to adverse events, mirror those from Ali et al

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GLP-1s work by mimicking the action of your GLP-1 hormone, which is naturally produced in the body and helps to regulate blood sugar levels, reduce hunger and cravings, and increase energy expenditure

A study found that liraglutide, a specific GLP-1RA, exhibited analgesic effects in animals by reducing inflammation in joint tissues

Those in the trial that did experience negative side effects did so at the same rate and consistency as those previously reported for injectable GLP-1 drugs and Eli Lilly said it "was consistent." The drugmaker said the most commonly reported negative side effects were mild to moderate gastrointestinal-related symptoms, such as nausea, constipation, indigestion, diarrhea and vomiting
