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Higher baseline deficiency risk in the target population Research has consistently shown that individuals with obesity have higher rates of B12 deficiency compared to the general population

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It mimics the GLP-1 hormone that is released in the gastrointestinal tract in response to eating

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As a GIP receptor agonist, tirzepatide enhances insulin secretion and may potentially improve insulin sensitivity while reducing glucagon secretion, though these mechanisms continue to be studied