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Receiver operating characteristic (ROC) analysis showed an area under the curve of 0.695 (95% CI 0.587-0.804, P = 0.001), with an optimal cutoff for fasting C-peptide reduction of 0.8% (specificity 75.2%, sensitivity 61.1%)

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[4] Coverage requires BMI 40 AND participation in weight loss program (diet, exercise, behavior therapy) Coverage for Type 2 diabetes remains unchanged Anthem Blue Cross California policies may differ BCBS Massachusetts Starting January 1, 2026, BCBS MA standard plans will exclude GLP-1s including Zepbound, Wegovy, and Saxenda for weight management